"While hematopoietic stem cell transplantation has proven curative potential, a significant need remains to reduce the morbidity and mortality associated with the procedure, including the risk of T-cell mediated complications such as viral infections, graft vs. host disease and delayed immune reconstitution," said Christian Weyer, M.D., M.A.S., President and Chief Executive Officer of Fate Therapeutics. "We are excited that our ex vivo programming platform has identified a combination of small molecule modulators that promote the supra-physiologic activation of genes implicated in the cell cycle, immune tolerance and anti-viral properties of T-cells, as well as in the survival, proliferation and engraftment potential of CD34+ cells. We believe these findings form a compelling scientific basis to support the clinical evaluation of ex vivo programmed mobilized peripheral blood in patients undergoing hematopoietic stem cell transplantation for the treatment of hematologic malignancies."
The data are being presented today during a poster presentation entitled "Ex Vivo Modulation of Mobilized Peripheral Blood: Characterization of HSC and T-Cell Responses to Small Molecule Modulation," and expand and build upon the clinical development of the Company's lead product candidate, PROHEMA®. PROHEMA, an ex vivo programmed hematopoietic cellular therapeutic which uses FT1050 (16,16 dimethyl prostaglandin E2 , or dmPGE2) to pharmacologically modulate umbilical cord blood, is currently being investigated in a Phase 2 clinical trial in adult patients and a Phase 1b clinical trial in pediatric patients with hematologic malignancies undergoing umbilical cord blood transplantation. As part of its continuing evaluation of the modulatory effects of FT1050 on hematopoietic cells, Fate Therapeutics identified a second small molecule modulator, referred to as FT4145, that synergizes with FT1050 to further enhance the pharmacological properties and the in vivo therapeutic potential of CD34+ cells and T-cells.
Gene expression analysis of CD34+ cells sourced from mobilized peripheral blood co-modulated with FT1050 and FT4145 showed a ~60-fold increase in the expression of the key homing receptor CXCR4, and ex vivo programmed CD34+ cells demonstrated a statistically significant increase in engraftment in preclinical models as compared to unmodulated cells. Additionally, genome-wide expression analysis of the T-cell compartment of mobilized peripheral blood, including CD8+, CD4+ and regulatory T-cells, revealed the induction of genes involved in cell cycle (e.g., CCND1, CCNE1), immune tolerance (e.g., DUSP5, FLT1) and anti-viral properties (e.g., CD55, EFNB2). Additionally, following a five-day culture in the presence of activating beads, T-cells co-modulated with FT1050 and FT4145 were found to have reduced proliferation rates and decreased cell-surface protein expression of ICOS, a key T-cell activation marker, relative to unmodulated cells.
Collectively, these preclinical findings point to the therapeutic potential for ex vivo programmed hematopoietic cells to mitigate T-cell mediated complications and improve outcomes in patients undergoing hematopoietic stem cell transplant with mobilized peripheral blood as a cell source. Mobilized peripheral blood is the predominant cell source used in hematopoietic stem cell (HSC) transplantation.
About Fate Therapeutics, Inc.
Fate Therapeutics is a clinical-stage biopharmaceutical company engaged
in the discovery and development of pharmacologic modulators of adult
stem cells to treat severe, life-threatening diseases. The Company's
approach utilizes established pharmacologic modalities, such as small
molecules, and targets well-characterized biological mechanisms to
program the fate and enhance the therapeutic potential of adult stem
cells. The Company's lead product candidate, PROHEMA®, is an ex vivo
programmed hematopoietic stem cell, or HSC, therapeutic, which is
currently in clinical development for patients undergoing HSC
transplantation. The Company is also applying its reprogramming
modulators to develop human induced pluripotent stem cell-derived
cellular therapeutics, and evaluating the in vivo programming of
muscle satellite stem cells using its Wnt7a-based protein analogs for
muscle regeneration. Fate Therapeutics is headquartered in San Diego,
CA. For more information, please visit www.fatetherapeutics.com.
This release contains "forward-looking statements" within the meaning
of the Private Securities Litigation Reform Act of 1995, including
statements regarding the therapeutic potential of PROHEMA® and ex vivo
programmed mobilized peripheral blood, the Company's plans with respect
to PROHEMA and other product candidates, and anticipated research and
development activities relating to the ex vivo programming of
hematopoietic cells, including T-cells. These and any other
forward-looking statements in this release are based on management's
current expectations of future events and are subject to a number of
risks and uncertainties that could cause actual results to differ
materially and adversely from those set forth in or implied by such
forward-looking statements. These risks and uncertainties include, but
are not limited to, the risks that the results of PROHEMA observed in
prior preclinical and clinical development may not be replicated or may
cause unanticipated adverse effects in current or subsequent clinical
trials of PROHEMA, the risk of cessation or delay of any clinical
development activities for a variety of reasons (including additional
information that may be requested or additional obligations that may be
imposed by the FDA, any difficulties or delays in patient enrollment in
current and planned clinical trials, and any adverse events or other
negative results that may be observed in these trials), or the risk that
we are unable to conduct or complete preclinical and clinical
activities necessary to advance any additional hematopoietic cellular
therapeutic product candidates, including any candidates derived from
mobilized peripheral blood. For a discussion of other risks and
uncertainties, and other important factors, any of which could cause our
actual results to differ from those contained in the forward-looking
statements, see the risks and uncertainties detailed in the Company's
periodic filings with the Securities and Exchange Commission, including
but not limited to the Company's Form 10-Q for the quarter ended
September 30th, 2014, and from time to time the Company's other investor
communications. Fate Therapeutics is providing the information in this
release as of this date and does not undertake any obligation to update
any forward-looking statements contained in this release as a result of
new information, future events or otherwise.
sources: http://globenewswire.com/
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